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Aldosterone Production After Suppression of Corticotropic Secretory Activity
Richard F. Spark;
Stephen J. Gordon;
Sidney L. Dale;
James C. Melby
Arch Intern Med. 1968;122(5):394-398.
Abstract
The effect of suppressive doses of glucocorticoids on aldosteronesecretion was studied. Dexamethasone in a dose of 2 mg/day fortwo days resulted in a 38% decrease in aldosterone secretoryrate (ASR) in 18 of 22 patients studied. Three of the four patientswho showed no decrease in ASR had primary aldosteronism. Angiotensininfusion increased ASR before and after dexamethasone suppression,but the rise in ASR after combined dexamethasone suppressionand angiotensin infusion was still 30% less than the control-unstimulatedASR. Sensitivity to endogenously generated angiotensin was similarlyblunted by dexamethasone suppression. It is concluded that suppressionof endogenous adrenocorticotropic activity significantly reducesthe adrenal secretory response to angiotensin.
