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Intestinal Disaccharidase Activity in Celiac Sprue (Gluten-Sensitive Enteropathy)
Jack D. Welsh, MD;
Opal M. Zschiesche, MD;
Juanetta Anderson;
Anthony Walker, BS
Arch Intern Med. 1969;123(1):33-38.
Abstract
Intestinal biopsy specimens from 22 patients with celiac sprue demonstrated the following: (1) Mean disaccharidase and alkaline phosphatase activities increased from low levels associated with severe mucosal lesions to higher levels with moderate or mild lesions. With mild histology, all enzymes assayed were normal, except for low lactase activity in 25%. (2) Comparison of paired specimens from adjacent sites revealed similar morphologic changes in 70% of the pairs. With respect to occurrence of normal or abnormal enzyme activity in the paired samples, lactase activity was the same in all pairs, while the other enzymes were the same in 74% to 86% of the pairs. (3) Although a clinical improvement followed fair adherence to a glutenfree diet, mild histologic changes and a complete return of enzyme activity occurred only in patients who had adhered strictly to the diet.
Author Affiliations
Oklahoma City
From the Department of Medicine, University of Oklahoma Medical Center and the Neurosciences Section, Oklahoma Medical Research Foundation, Oklahoma City. Doctor Zschiesche was a Gastroenterology trainee of the Public Health Service.
Footnotes
Received for publication Feb 28, 1968; accepted Sept 16.
Reprint requests to Department of Medicine, University of Oklahoma Medical Center, 800 NE 13th St, Oklahoma City 73104 (Dr. Welsh).
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