 |
|
Hemodynamic Responses to Chlorpromazine in Patients in Shock
Henry S. Loeb, MD;
Raymond J. Pietras, MD;
Nicholas Ninos, MD;
John R. Tobin, Jr., MD;
Rolf M. Gunnar, MD
Arch Intern Med. 1969;124(3):354-358.
Abstract
Hemodynamic measurements were obtained from 18 patients in shock before and after administration of chlorpromazine. Mean arterial pressure fell in all but one patient due to a reduction in systemic vascular resistance. Improved cardiac output occurred in nine patients, who, when compared to the others, had higher arterial and central venous pressures, higher vascular resistances, and had shown a poorer response to plasma volume expansion. These observations suggest that chlorpromazine will reduce vascular resistance in most patients in shock, but will not improve cardiac output if central aortic pressure is low or previous fluid replacement has been inadequate.
Author Affiliations
Chicago
From the Hektoen Institute for Medical Research, Cook County Hospital; and the departments of medicine, University of Illinois College of Medicine (Drs. Loeb, Pietras, and Gunnar) and Loyola University Stritch School of Medicine, Chicago (Dr. Tobin). Dr. Loeb was a research fellow of the Chicago Heart Association and was supported by grant F67-1. Dr. Ninos was a fellow in cardiology at Cook County Hospital.
Footnotes
Received for publication Sept 25, 1968; accepted April 16, 1969.
Reprint requests to Department of Adult Cardiology, Cook County Hospital, 1825 W Harrison St, Chicago 60612 (Dr. Gunnar).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
|
