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Clinical Experience With Human Growth Hormone Immunoassay by a Two-Antibody Method
Robert W. Ewer, MD;
William P. Deiss, Jr., MD
Arch Intern Med. 1969;124(4):461-467.
Abstract
Serum human growth hormone (HGH) content was determined in 150 participants by a two-antibody immunoassay. Some subjects concealed taking medication, especially progestogens causing increases of HGH. Physiologic doses of estrogens increased serum HGH values in fasting, ambulant women but not in men. High HGH values were found in patients with acromegaly or acromegaly-gigantism, in patients with anorexia nervosa or islet cell tumor of the pancreas, and in one with chromophobe adenoma of the pituitary. Exercise and insulin- or tolbutamide-induced hypoglycemia were the most reliable provocative tests for HGH. Intravenous arginine infusion was least reliable. Exaggerated HGH responses to hypoglycemia were observed in a patient with persistent lactation and amenorrhea; and impaired responses were observed in patients with anorexia nervosa, pituitary basophilism (Cushing's disease) thyrotoxicosis, and obese subjects.
Author Affiliations
Galveston, Tex
Footnotes
Received for publication Jan 27, 1969; Accepted Feb 4.
From the Indiana University Medical Center, and the Welborn Clinic and Welborn Memorial Baptist Hospital, Evansville, Ind. Drs. Ewer and Deiss are now with the University of Texas Medical Branch, Galveston, Tex.
Reprint requests to University of Texas Medical Branch, Galveston 77550 (Dr. Ewer).
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