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The Effect of Propranolol in the Long-Term Treatment of Angina Pectoris
Howard J. Zeft, MD;
Sandra Patterson, BSN;
Edward S. Orgain, MD
Arch Intern Med. 1969;124(5):578-583.
Abstract
The effect of propranolol hydrochloride in the long-term treatment of angina pectoris was evaluated in 65 patients with severe ischemic (coronary artery) heart disease; 57 were followed up for 6 to 24 months and of these, 37 exhibited a sustained 50% reduction in the frequency of anginal pains and 36 of 54 had a 50% reduction in nitroglycerin requirements. Each patient had a dose threshold (between 160 to 400 mg per day) at which maximum relief was attained. Eight of 65 patients died of myocardial infarction or suddenly; 6 had congestive heart failure; 2, asthma; and 3, severe gastrointestinal symptoms. The results indicate a long-term beneficial effect of propranolol in angina pectoris for periods up to two years. Despite significant symptomatic improvement, a mortality of 12.3% suggests that propranolol does not alter the natural history of severe coronary artery disease.
Author Affiliations
Durham, NC
From the Cardiovascular Disease Service, Division of Cardiology, Department of Medicine, Duke University Medical; Center, Durham, NC.
Footnotes
Received for publication Jan 30, 1969; accepted June 4.
Reprint requests to PO Box 3085, Duke University Medical Center, Durham, NC 27706 (Dr. Orgain).
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