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Propranolol in Angina Pectoris
Thomas T. Zsotér, MD;
Donald S. Beanlands, MD
Arch Intern Med. 1969;124(5):584-587.
Abstract
Twenty patients with angina pectoris received propranolol hydrochloride at two dosage levels and placebo in a double-blind trial. The lower dosage of propranolol hydrochloride (80 mg/day) failed to reduce the frequency of anginal attacks. The higher dosage of propranolol hydrochloride (160 mg/day), however, decreased the number of daily pain episodes in 17 patients and the amount of nitroglycerin consumed (P <0.02). No correlation was found between the response to the drug and the left ventricular end diastolic (LVED) pressure measured prior to the drug trial. Propranolol was effective also in patients with severe coronary disease judged from coronary angiography, but there was a trend toward better results in patients with less severe involvement of the coronary arteries. Exercise tolerance became greater on the regimen of propranolol. Adverse effects were never severe enough to warrant stopping the trial.
Author Affiliations
Toronto
From the Department of Medicine, University of Toronto, and the subdepartments of clinical pharmacology and; cardiology of the Department of Medicine, Toronto Western Hospital.
Footnotes
Received for publication Jan 9, 1969; accepted May 8.
Reprint request to 399 Bathurst St, Toronto 2B (Dr. Zsotér).
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