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Essential CryoglobulinemiaImmunologic Studies Before and After Penicillamine Therapy
Leonard S. Goldberg, MD;
Eugene V. Barnett, MD
Arch Intern Med. 1970;125(1):145-150.
Abstract
Immunologic investigation of a patient with essential ( G-M) cryoglobulinemia was performed before and after a six-month course of oral treatment with penicillamine. Marked reductions in the amount of cryoprecipitation and in the levels of serum immunoglobulins (G, A and M) were the most striking effects of this therapy. Moreover, there was a reversal in the ratio of G to M molecules in the cryoprecipitate; prior to treatment, the G:M ratio was 1:2 and after, 7:1. These immunologic changes suggest that penicillamine suppressed the synthesis of G, A, and M, although it appeared to preferentially suppress the cryoprecipitable M. Despite the immunologic response to penicillamine, the patient's symptoms did not im prove. Persistence of symptoms may be explained by the irreversible peripheral vascular disease existing prior to therapy.
Author Affiliations
Los Angeles
From the Rheumatology Section, Department of Medicine, UCLA School of Medicine, Los Angeles.
Footnotes
Submitted for publication March 20, 1969; accepted, April 25.
Reprint requests to 1000 Veterans Ave, Los Angeles 90024 (Dr. Goldberg).
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