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Uremic Patients

Karim Mansouri, MD; James A. Halsted, MD; Ervin A., MD

Arch Intern Med. 1970;125(1):88-93.

Abstract
Increasingly, long-term hemodialysis is being implicated causally in the development of metabolic disturbances. Complications such as bone disease and neuropathy have been observed and the role of trace metals in their development has been questioned. In 15 uremic patients who underwent hemodialysis, plasma and erythrocyte content of zinc, copper, magnesium, and calcium was determined before and after a single dialysis and compared to values obtained in seven nondialyzed uremics. Uremic patients receiving severely restricted protein intake and not dialyzed had low plasma zinc and normal copper levels, high plasma and erythrocyte magnesium and low plasma and erythrocyte calcium levels. In dialyzed uremic patients with more liberal protein intake the plasma zinc levels approached normal. The effect of a single dialysis on these values was not striking; the role of the diet could not be ascertained.

Author Affiliations
Washington, DC

From the Trace Element Research Laboratory, the Nephrology Section and Hemodialysis Unit, Veterans Administration Hospital; and the departments of; medicine, epidemiology, and environmental health, George Washington University School of Medicine, Washington, DC.

Footnotes
Received for publication Oct 15, 1968; accepted April 15, 1969.

Reprint requests to 550 First Ave, New York 10016 (Dr. Gombos).

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