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John F. Maher, MD; George E. Schreiner, MD

Arch Intern Med. 1970;125(2):293-298.

Abstract
Azathioprine (1.7 to 4.3 mg/kg/day) was administered to 11 patients with nephritis of systemic lupus erythematosus (LE) (positive LE cell test). Prior therapy with prednisone was ineffective, had toxic effects, or both. Sustained improvement in nephritis (hematuria, proteinuria, serum electrolytes, edema) occurred gradually in three patients, transient improvement occurred in two, immunologic improvement occurred in only one patient and five (three uremic) patients were not improved. Four patients died during or shortly after therapy of 7 to 53 days duration. Azathioprine-induced remissions of prednisone-resistant lupus nephritis were infrequent. Some remissions did not occur until after leukopenia and systemic infection had complicated therapy.

Author Affiliations
Washington, DC

From the Renal and Electrolyte Division, Department of Medicine, Georgetown University School of Medicine, Washington, DC.

Footnotes
Received for publication Aug 18, 1969; accepted Oct 21.

Reprint requests to 807 Stadium Rd, Columbia, Mo 65201 (Dr. Maher).

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