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Failure

Norman M. Simon, MD; Norman H. Bell, MD; Francesco del Greco, MD

Arch Intern Med. 1970;125(2):299-301.

Abstract
Seven patients with renal failure of varying etiology had abnormalities in urinary excretion and plasma content of the imino acids (proline and hydroxyproline) and of glycine. Urinary excretion of proline and free hydroxyproline was increased, while peptide hydroxyproline and glycine excretion were normal. Plasma levels of the imino acids and glycine were elevated. The metabolic abnormalities appeared in one patient as renal failure developed and disappeared in two patients after successful renal transplantation. Partial parathyroidectomy or calcium infusion in two patients decreased the iminoaciduria. Osteitis fibrosa was present in four of six bone specimens. The findings suggest that the iminoacidopathy is acquired during the course of chronic renal failure, due in part to secondary hyperparathyroidism.

Author Affiliations
Chicago

From the Department of Medicine, Northwestern University Medical School and Passavant Memorial Hospital, Chicago. Dr. Bell is now with the Veterans Administration Hospital and the University of Indiana Medical School, Indianapolis.

Footnotes
Received for publication July 29, 1969; accepted Sept 22.

Reprint requests to 303 E Superior St, Chicago 60611 (Dr. Simon).

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