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Ralph Ryback, MD; Jane Desforges, MD

Arch Intern Med. 1970;125(3):475-477.

Abstract
Three known alcoholics without medical complications were given alcohol ad lib. Platelets were counted periodically during and following the period of drinking. There was an initial transient decline in platelet levels. A more gradual decline then occurred after the second day. Upon cessation of drinking there was a slow recovery of platelet values. None of the subjects showed evidence of liver disease, folate deficiency, or intravascular coagulation. The results suggest that alcohol has a direct effect on platelet turnover.

Author Affiliations
Boston

From the Alcoholic Study Unit, Boston City Hospital and Harvard Medical School (Dr. Ryback) and the Tufts Hematology Laboratory, Boston City Hospital (Dr. Desforges).

Footnotes
Received for publication March 25, 1969; accepted April 18.

Reprint requests to 818 Harrison Ave, Boston 02118 (Dr. Desforges).

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