This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (99)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert M. Glasser, MD; Richard I. Walker, MD; John C. Herion, MD

Arch Intern Med. 1970;125(4):691-695.

Abstract
The records of 40 patients with miliary tuberculosis and 24 others with both tuberculosis and significant hematologic abnormalities were reviewed to see if the hematologic changes represented primary diseases or were secondary to tuberculosis. Leukopenia, leukocytosis, monocytosis, and anemia are certainly responses to tuberculosis because they disappear following antituberculous treatment. Patients with tuberculosis and leukemic blood pictures or pancytopenia do not survive with use of antituberculous therapy alone. A likely explanation for this is that underlying hematologic disease is present and greatly contributes to the invariably fatal outcome. Since no patient with tuberculosis and pancytopenia has been reported to recover with antituberculous therapy alone, there appears to be no basis for considering tuberculosis a "treatable cause" of pancytopenia.

Author Affiliations
Chapel Hill, NC

From the Division of Hematology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

Footnotes
Received for publication June 25, 1969; accepted Jan 8, 1970.

Reprint requests to University of North Carolina School of Medicine, Chapel Hill 27514 (Dr. Walker).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A study of clinico-haematological profiles of pancytopenia in children
Gupta et al.
Trop Doct 2008;38:241-243.
ABSTRACT | FULL TEXT  

Severe Immune Hemolytic Anemia in Disseminated Tuberculosis With Response to Antituberculosis Therapy
Kuo et al.
Chest 2001;119:1961-1963.
ABSTRACT | FULL TEXT  

Case 23-1995- A 44-year-old woman with pulmonary infiltrates, respiratory failure, and pancytopenia
Benatar and Mark
NEJM 1995;333:241-248.
FULL TEXT  

Tuberculosis: Missed Opportunities
Kissner
Arch Intern Med 1987;147:2037-2040.
ABSTRACT  

Immune Thrombocytopenia Associated with Tuberculosis
Jurak et al.
CLIN PEDIATR 1983;22:318-319.
ABSTRACT  

A Hypereosinophilic Syndrome With Retinal Arteritis and Tuberculosis
Farcet et al.
Arch Intern Med 1982;142:625-627.
ABSTRACT  

Suppression of Granulopoiesis by T-Lymphocytes in Two Patients with Disseminated Mycobacterial Infection
BAGBY and GILBERT
ANN INTERN MED 1981;94:478-481.
ABSTRACT  

Bone Marrow Necrosis From Miliary Tuberculosis
Katzen and Spagnolo
JAMA 1980;244:2438-2439.
ABSTRACT  

Disseminated Scotochromogen Infection and Unusual Myeloproliferative Disorder: Report of a Case and Review of the Literature
MCNUTT and FUDENBERG
ANN INTERN MED 1971;75:737-744.
ABSTRACT