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Interrelationships in Normal Men Under Stress

LCDR Robert T. Rubin, MC; LCDR Richard H. Rahe, MC; Brian R. Clark; CAPT Ransom J. Arthur, MC

Arch Intern Med. 1970;125(5):815-819.

Abstract
Repeated determinations of serum uric acid, cholesterol, and cortisol levels were done three times a week on 20 healthy young Navy men during a 16-week underwater demolition team (UDT) training course, a period of considerable physical and psychological stress. The intraindividual correlations between uric acid and cholesterol levels, uric acid and cortisol levels, and cholesterol and cortisol levels all showed a considerable range of values, both positive and negative, and several of the correlations were statistically significant. However, across-subjects correlations of the mean values of these measures were of low order, which indicated that a cross-sectional sampling design can mask the considerable variability in intraindividual values. This variability indicates that there can be a considerable individuality in patterns of biochemical response and adaptation to stress.

Author Affiliations
USNR; USNR; USN, San Diego, Calif

From the Navy Medical Neuropsychiatric Research Unit, San Diego, Calif, and the Department of Psychiatry, University of California at Los Angeles School of Medicine.

Footnotes
Received for publication Sept 24, 1969; accepted Dec 2.

Opinions expressed are those of the authors and are not to be construed as necessarily reflecting the official view or endorsement of the Navy Department.

Reprint requests to 760 Westwood Plaza, Los Angeles 90024 (Dr. Rubin).

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