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Its Use In Patients With Raynaud's Disease or Raynaud's Phenomenon

Stephen G. Romeo, MD; Robert E. Whalen, MD; John P. Tindall, MD

Arch Intern Med. 1970;125(5):825-829.

Abstract
Eighteen patients with either Raynaud's disease or Raynaud's phenomenon were given reserpine intra-arterially (1 mg) into one or both brachial arteries. Responses were graded 0 to 3+. Of the 12 patients with Raynaud's phenomenon, three showed a 3+ response, four showed a 2+ response, one showed a 1+ response, and four showed no response. Of the six patients with primary Raynaud's disease, three showed a 3+ response, none showed a 2+ response, one showed a 1+ response, and two showed no response. The average duration of clinical effectiveness was approximately seven months and side effects were minimal. Intraarterial administration of reserpine for Raynaud's disease and Raynaud's phenomenon deserves further clinical evaluation.

Author Affiliations
Durham, NC

From the dermatology and cardiovascular divisions, Department of Medicine, Duke University Medical Center, Durham, NC.

Footnotes
Received for publication Oct 2, 1969; accepted Jan 15, 1970.

Reprint requests to Duke University Medical Center, Durham, NC 27706 (Dr. Whalen).

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