This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (27)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Analysis of Lysozymuria, Serum Complement, Lymphocyturia, and Heterophil Antibodies

Isam H. Shehadeh, MD; Charles B. Carpenter, MD; Clyde H. Monterio, MD; John P. Merrill, MD

Arch Intern Med. 1970;125(5):850-857.

Abstract
Daily determinations of urinary lysozyme levels, serum β_1C (C3) and β_1E (C4)globulin concentrations, number of small mononucleated cells in the urinary sediment, and serum heterophil-antibody titers were carried out in 22 patients undergoing renal allotransplantation in order to determine which of these alterations are related to rejection episodes. Small mononuclear cells appeared in the urinary sediment at irregular intervals and displayed no relationship to onset of rejection. Similarly, heterophil-antibody titers rose in relation to only half the episodes of acute rejection, and similar fluctuations were observed in six of 11 patients who did not undergo acute rejection reactions. Urinary lysozyme excretion, on the other hand, was a sensitive indicator of renal tubular damage, and instability of serum complement levels occurred during clinically diagnosed rejection episodes.

Author Affiliations
Boston

From the Department of Medicine, Peter Bent Brigham Hospital, and Harvard Medical School, Boston. Dr. Shehadeh is a Commonwealth Fund Fellow. Dr. Carpenter is a recipient of a National Institutes of Health Career Research Development Award. Dr. Merrill is an investigator of the Howard Hughes Medical Institute, Miami, Fla.

Footnotes
Received for publication Sept 24, 1969; accepted Nov 18.

Read in part before the 81st annual meeting of the American Federation for Clinical Research, Atlantic City, NJ, May 5, 1968.

Reprint requests to 721 Huntington Ave, Boston 02115 (Dr. Carpenter).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?