This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (68)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Prospective Study

Eugene L. Klingler, Jr., MD; Carlos A. Vaamonde, MD; Liliana S. Vaamonde, MD; Ruben G. Lancestremere, MD; Hugo J. Morosi, MD; Emanuel Frisch, MD; Solomon Papper, MD

Arch Intern Med. 1970;125(6):1010-1015.

Abstract
Thirteen patients with cirrhosis had sequential studies of renal function done as their clinical state deteriorated or improved; four others were studied as renal failure developed. While some patients with severe liver disease had an increase in renal function when their condition improved, renal function bore no consistent relation to clinical severity, changes in water and sodium excretion rates were not consistently accompanied by changes in glomerular filtration rate, and cardiac output did not change consistently with the clinical state. These discrepancies indicate that the cause or causes of the abnormalities in renal function do not correlate consistently with guides generally employed to estimate clinical severity, and suggest that the observed alterations in renal function may not have a single pathogenesis. There was no apparent way to distinguish which of the decompensated patients would develop renal failure.

Author Affiliations
Albuquerque; Miami; Richmond; Albuquerque; Richmond; Miami

From the Department of Medicine, University of New Mexico School of Medicine, and the Medical Service, the Veterans Administration Hospital and Bernalillo County Medical Center, Albuquerque (Drs. Klingler and Morosi), the Department of Medicine, Medical College of Virginia, Richmond (Drs. Lancestremere and Frisch), and the Department of Medicine, University of Miami School of Medicine, and the Medical Service, the Veterans Administration Hospital, Miami (Drs. C. Vaamonde, L. Vaamonde, and Papper). Drs. Lancestremere and Morosi are now with the University of Buenos Aires, Buenos Aires. Dr. Frisch is now in private practice in Detroit.

Footnotes
Received for publication Jan 23, 1970, accepted Feb 17.

Reprint requests to 2100 Ridgecrest Dr SE, Albuquerque 87108 (Dr. Klingler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Glomerular Dynamics
Fried and Stein
Arch Intern Med 1983;143:787-791.
ABSTRACT  

Role of Vasopressin in Abnormal Water Excretion in Cirrhotic Patients
BICHET et al.
ANN INTERN MED 1982;96:413-417.
ABSTRACT