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C. Jack Smith, MD; Fred E. Hatch, MD; James Gibb Johnson, MD; Bobby J. Kelly, MD

Arch Intern Med. 1970;125(6):1022-1026.

Abstract
Two young male patients with neurofibromatosis were found to have intrinsic abnormalities of the renal arteries which produced renovascular hypertension. The vascular lesions in both patients appeared to consist of dysplastic lesions of the arterial wall rather than compression or involvement of the renal artery with neurofibromata. One patient demonstrated vascular lesions involving three major renal arteries. In addition, intimal proliferation and fibromuscular changes in the media were observed in the small arteries of the renal parenchyma. Surgical correction of the main renal artery lesions in this case produced a poor antihypertension response, while correction of the arterial stenosis in the patient without small vessel involvement invoked a hypertensive cure. Hypertension associated with neurofibromatosis may be produced by a variety of vascular lesions among which are dysplastic abnormalities of the large and small renal arteries.

Author Affiliations
Memphis

From the Section of Nephrology, Department of Medicine, University of Tennessee College of Medicine, Memphis. Dr. Smith was a postdoctoral fellow of the Tennessee Heart Association and is now in private practice in Texarkana, Tex.

Footnotes
Received for publication Oct 23, 1969; accepted Feb 17, 1970.

Reprint requests to 953 Court Ave, Suite 353 D, Memphis 38103 (Dr. Hatch).

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