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Live and Inactivated Adenovirus VaccinesClinical Evaluation of Efficacy in Prevention of Acute Respiratory Disease
John P. Griffin, MD;
Burton H. Greenberg, MD
Arch Intern Med. 1970;125(6):981-986.
Abstract
Clinical evaluation of a live orally administered adenovirus 4 vaccine was conducted at the Naval Training Center, Great Lakes, III. In a double-blind epidemiologic investigation the effectiveness of this newer vaccine was compared to that of two other inactivated adenovirus 4 vaccines and appropriate placebos in a population of 2,307 recruits. By detailed clinical examination of all participants requiring hospitalization (644 admissions), syndrome-specific incidences of acute undifferentiated respiratory disease (ARD) and of other respiratory syndromes were derived. Each of the adenovirus vaccines effected a similar 50% to 60% relative reduction of ARD, as well as symptomspecific decreases in the incidence of clinical manifestations of ARD. No evidence of a clinical toxic effect of the live adenovirus vaccine administered orally was detected.
Author Affiliations
Great Lakes, Ill
From the Epidemiology Division, US Naval Medical Research Unit No. 4, Great Lakes, Ill. Dr. Griffin is now with University of Tennessee College of Medicine, Memphis. Dr. Greenberg is now with Mayo Clinic and Research Foundation, Rochester, Minn.
Footnotes
Received for publication Sept 24, 1969; accepted Jan 28, 1970.
The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the Naval Service at large.
Reprint requests to 951 Court Ave, Memphis 38103 (Dr. Griffin).
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