This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (15)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joseph R. Bianchine, MD; Arnold P. Friedman, MD

Arch Intern Med. 1970;126(2):252-254.

Abstract
The metabolism of methysergide was studied in five healthy adult subjects and three patients who had previously developed retroperitoneal fibrosis while receiving long-term therapy with ¹⁴C-methysergide maleate. All patients were asymptomatic and had normal renal function at the time of study. Subjects and patients did not differ in regard to serum radioactivity data or urinary excretion of total radioactivity and methysergide radioactivity. They also excreted radioactive carbon dioxide (¹⁴CO₂) into the expired air at similar rates, suggesting that both groups were able to demethylate methysergide to form methergine. These three patients thus appear to metabolize a single test dose of methysergide in a normal manner; the pathogenesis of retroperitoneal fibrosis in such patients remains unknown.

Author Affiliations
Baltimore; New York

From the Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore (Dr. Bianchine) and the Headache Unit, Montefiore Hospital and Medical Center, New York (Dr. Friedman).

Footnotes
Received for publication Nov 20, 1969; accepted March 10,1970.

Reprint requests to Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore 21205 (Dr. Bianchine).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Screening of Antiserotoninergic Drugs With the Genetically Dystrophic Chicken
Hudecki et al.
Arch Neurol 1980;37:545-550.
ABSTRACT