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A Basis for Respiratory Models

Paul E. Morrow, PhD

Arch Intern Med. 1970;126(3):466-470.

Abstract
Recent technological advancements and newly available radioactive, isotopic aerosols have accelerated and broadened experimental investigations of dust deposition and retention in the human respiratory system. Collectively, these studies have provided a much improved basis for designing respiratory models of interest and value to biomedical research, and particularly to environmental scientists, occupational hygienists, and health physicists. This communication reviews these models chronologically and includes some recent information which appears to correlate deposition and clearance to measurements of the inhaled aerosol. It concludes with a brief critique.

Author Affiliations
Rochester, NY

From the Department of Radiation Biology and Biophysics, University of Rochester, Rochester, NY.

Footnotes
Received for publication Jan 27, 1970; accepted March 23.

Reprint requests to Department of Radiation Biology and Biophysics, University of Rochester, Rochester, NY 14620.

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