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Jacinto J. Vazquez, MD

Arch Intern Med. 1970;126(3):471-474.

Abstract
The lung may be the site of organ-specific and non-organ-specific immunopathologic changes. These alterations are operational at two defensive locations, the bronchovascular "barrier" and the alveolovascular "barrier." The subepithelial bronchovascular barrier concentrates plasma proteins and fibrogen in asthma and similar disorders. The alveolovascular barrier is the site of localization of autoantibody directed against alveolar basement membrane in patients with Goodpasture's syndrome and in experimental pneumotoxic alveolitis. Immunopathogenic mechanisms may operate in a variety of pulmonary diseases. Further investigation is encouraged.

Author Affiliations
Durham, NC

From the Department of Pathology, Duke University Medical Center, Durham, NC.

Footnotes
Received for publication Jan 27, 1970; accepted March 16.

Read before the session entitled Integration of Responses and Model Systems (Peter T. Macklem, PhD, chairman) of the workshop on Pulmonary Responses to Inhaled Materials: An Evaluation of Model Systems, Castle Harbour, Bermuda, Oct 24,1969.

Reprint requests to Department of Pathology; Duke University Medical Center, Durham, NC 27706.

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ABSTRACT