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Joe R. Wardell, Jr., PhD; Lawrence W. Chakrin, PhD

Arch Intern Med. 1970;126(3):488-490.

Abstract
A canine model is described in which a segment of the cervical trachea is separated and formed in situ into a subcutaneously buried pouch. Some of the possible applications of the canine tracheal-pouch model to studies on inhalation toxicity are the following: (1) the separation of direct from reflex-induced effects of irritants on respiratory airway tissue in situ, (2) the study of various factors believed to be involved in the pathogenesis of mucus hypersecretion states (both independently and in relation to one another), and (3) the correlation of possible changes in chemical composition and physical properties of mucus secreted in response to irritants with histological and histochemical changes in the mucus-secreting structures in situ.

Author Affiliations
Philadelphia

From Smith, Kline and French Laboratories, Philadelphia.

Footnotes
Received for publication Jan 27, 1970; acaccepted March 2.

Read before the session entitled Integration of Responses and Model Systems (Peter T. Macklem, PhD, chairman) of the workshop on Pulmonary Responses to Inhaled Materials: An Evaluation of Model Systems, Castle Harbour, Bermuda, Oct 24,1969.

Reprint requests to 1500 Spring Garden St, Philadelphia 19101 (Dr. Wardell).

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