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Streptozotocin Therapy for Metastatic Insulinoma
Samuel G. Taylor III, MD;
Theodore B. Schwartz, MD;
John J. Zannini, MD;
Will G. Ryan, MD
Arch Intern Med. 1970;126(4):654-657.
Abstract
Streptozotocin, an antibiotic derived from Streptomyces achromogenes, was selected for treatment of a previously diabetic patient with incapacitating hypoglycemia caused by an islet cell carcinoma that had metastasized to the liver. Complete control of all symptoms, together with normalization of biochemical measurements, disappearance of evidence of hepatic metastases as shown on liver scan, and return to his pretumor diabetic state, have been accomplished without the development of a serious toxic reaction. This antibiotic appears to be useful in the control of insulinomas not amenable to surgery. Significant laboratory observations over an 80-day period of treatment are presented.
Author Affiliations
Chicago; Lake Forest, Ill; Chicago
From Presbyterian-St. Luke's Hospital and the University of Illinois, Chicago (Drs. Taylor, Schwartz, and Ryan), and Lake Forest (111) Hospital (Drs. Taylor and Zannini).
Footnotes
Received for publication March 27; 1970; accepted April 3.
Reprint requests to 1753 W. Congress Parkway, Chicago 60612 (Dr. Taylor).
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