 |
|
Brain Metabolism in Experimental Uremia
Stanley van den Noort, MD;
Robert E. Eckel, MD;
Katherine L. Brine;
Jeffry Hrdlicka
Arch Intern Med. 1970;126(5):831-834.
Abstract
The concentration and flux of adenine nucleotides and glycolytic intermediates were studied in brains of uremic rats and in rats infused with adenosine. Blood total adenine nucleotide levels were normal in uremic rats and raised in those infused with adenosine. Brain total adenine nucleotide levels were normal in both groups. In uremia and following adenosine infusion, brain levels of creatine phosphate (CP), adenosine triphosphate (ATP), and glucose increased, while creatine, adenosine diphosphate (ADP), adenosine monophosphate (AMP), and lactate decreased. Whole brain Na+ K+ adenosine triphosphatase (ATPase) was normal in uremic rats. Brain metabolic rate was reduced in uremic rats. It is suggested that uremia, like anesthesia, depresses brain utilization of ATP without detected inhibition of the capacity to produce ATP. Adenosine infusion, like sleep, permits normal utilization of ATP but enhances the potential for ATP synthesis.
Author Affiliations
Cleveland
From the Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, Cleveland.
Footnotes
Received for publication June 23, 1970; accepted July 7.
Read before the session entitled "Neurologic Disorders" (H. Richard Tyler, MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Disorders, Monterey, Calif, March 18,1970.
Reprint requests to Department of Medicine, Division of Neurology, Case Western Reserve University, School of Medicine, 2065 Adelbert Rd, Cleveland 44120 (Dr. van den Noort).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
