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Piero L. Balestri, MD; Marco Biagini, MD; Paolo Rindi, MD; Sergio Giovannetti, MD

Arch Intern Med. 1970;126(5):843-845.

Abstract
We attempted to reproduce both in vivo and in vitro some of the abnormalities of calcium, lipid, and carbohydrate metabolism known to occur in uremia. Preliminary results showed impaired intestinal absorption of calcium and plasma lipid abnormalities similar to those found in human uremia in dogs following long-term intoxication with methylguanidine. Abnormal results of intravenous glucose tolerance tests were observed in dogs intoxicated with urea, and the in vitro utilization of glucose by red blood cells was found to be inhibited by urea and creatinine.

Author Affiliations
Pisa, Italy

From the Centro Nefrologico Università di Pisa and Divisione Nefrologica Ospedali S Chiara, Pisa, Italy.

Footnotes
Received for publication July 8, 1970; accepted July 16.

Read before the session entitled "Protein Metabolism" (Carmelo Giordano, MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Diseases, Monterey, Calif, March 19, 1970.

Reprint requests to Divisione Nefrologica Ospedali S Chiara, 56100-Pisa, Italy (Dr. Giovannetti).

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