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Frederic B. Westervelt, Jr., MD

Arch Intern Med. 1970;126(5):865-869.

Abstract
Preliminary explorations of in vitro whole blood and leukocyte glucose and lactate metabolism in response to insulin are reported in a further effort to characterize the glucose intolerance of uremia. Data from previous studies of forearm response to insulin are reviewed. Uremic leukocytes seem to be less responsive than normal in terms of glucose uptake and utilization, and to exhibit an increase, rather than decrease, in lactate synthesis under the conditions employed. The possibility of a defect in uremic erythrocyte glucose uptake is suggested.

Author Affiliations
Charlottesville, Va

From the Renal Division, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville.

Footnotes
Received for publication July 8, 1970; accepted July 16.

Read before the session entitled "Intermediary Metabolic Disorders" (Edwin L. Bierman, MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Diseases, Monterey, Calif, March 19,1970.

Reprint requests to Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Va 22901 (Dr. Westervelt).

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