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An Unrecognized Abnormality in Triglyceride Production and Removal

John D. Bagdade, MD

Arch Intern Med. 1970;126(5):875-881.

Abstract
Basal plasma triglyceride (TG) concentrations were increased in 13 patients with non-nephrotic uremia who were not receiving dialysis therapy (164 ± 62 mg/100 ml, mean ± SD) and 25 uremic patients who were undergoing dialysis (276 ± 250 mg/100 ml). Basal immunoreactive insulin levels of both uremic groups were higher than nonuremic subjects of the same weight. In the group undergoing dialysis triglyceride and immunoreactive insulin (IRI) were directly related (r = 0.58, P < 0.02), which suggests that increased hepatic synthesis of triglyceride-rich lipoprotein may contribute to triglyceride elevation in uremia. In addition, peak postheparin lipolytic activity, an indirect estimate of tissue lipoprotein lipase and triglyceride removal capacity, was subnormal in all uremic subjects. Hypertriglyceridemia appears to be a previously unrecognized consequence of non nephrotic uremia. Alteration in both triglyceride production and assimilation may contribute to this abnormality.

Author Affiliations
Seattle

From the Division of Metabolism, Seattle Veterans Administration Hospital and the Department of Medicine, University of Washington School of Medicine, Seattle.

Footnotes
Received for publication July 8, 1970; accepted July 16.

Read before the session entitled "Intermediary Metabolic Disorders" (Edwin L. Bierman, MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Diseases, Monterey, Calif, March 19,1970.

Reprint requests to 4435 Beacon Ave South, Seattle 98108 (Dr. Bagdade).

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