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Effect of Chronic Uremia on Collagen Metabolism in Skin and Bone
Theodore J. Hahn, MD;
Louis V. Avioli, MD
Arch Intern Med. 1970;126(5):882-886.
Abstract
The bone of rats made chronically uremic by segmental infarction of one kidney and contralateral nephrectomy exhibited a decrease in mature collagen and an increase in early soluble collagen content, suggesting a maturation block in bone collagen induced by the uremic state. The mature and soluble collagen contents of skin in uremic rats was unchanged. Kinetic studies of bone collagen formation with proline tagged with carbon 14 revealed both a decrease in collagen maturation and demonstrated an increase in mature collagen degradation.
Author Affiliations
St. Louis
From the Department of Medicine, Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis.
Footnotes
Received for publication July 8, 1970; accepted July 16.
Read before the session entitled "Mineral Metabolism" (Hillel J. Gitelman; MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Diseases, Monterey, Calif, March 20, 1970.
Reprint requests to Department of Medicine, Washington University School of Medicine, St. Louis 63110 (Dr. Avioli).
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