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The Nature of Vitamin D Resistance in Experimental Uremia
Daniel V. Kimberg, MD;
Richard D. Baerg, MD;
Elaine Gershon
Arch Intern Med. 1970;126(5):891-895.
Abstract
The diminished absorption of calcium and the osteodystrophy which accompany chronic renal disease are often "resistant" to vitamin D. The basis for this resistance remains uncertain. Recent studies have emphasized the role of an abnormality in vitamin D metabolism in accounting for the alterations in calcium absorption and the apparent vitamin D resistance which occur in renal failure. The results of experiments in this laboratory with a uremic animal model strongly suggest that in addition to the proposed mechanism involving an interference with the metabolism of vitamin D, renal insufficiency also affects the cellular reactions mediating calcium transport in a manner which, while opposite in direction to that of vitamin D, is independent of a direct interaction with the vitamin or its metabolites.
Author Affiliations
Boston; New York; Boston
From the departments of medicine, Harvard Medical School and Beth Israel Hospital Boston (Dr. Kimberg and Miss Gershon) and Columbia University College of Physicians and Surgeons, New York (Dr. Baerg).
Footnotes
Received for publication July 8, 1970; accepted July 16.
Read before the session entitled "Mineral Metabolism" (Hillel J. Gitelman, MD, chairman) of the Symposium on Uremic Toxins sponsored by the National Institute of Arthritis and Metabolic Diseases, Monterey, Calif, March 20, 1970.
Reprint requests to 330 Brookline Ave, Boston 02215 (Dr. Kimberg).
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