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John H. Knelson, MD

Arch Intern Med. 1971;127(3):421-425.

Abstract
Recent advances in developmental biology suggest that alterations in functional maturation of specific organs may serve as a model to assess adverse effects of environmental factors. Maturation of the mammalian lung depends on integrity of the hypothalamic-pituitary-adrenal axis controlling glucocorticoid production and interference with this system retards or prevents acquisition by the lung of factors essential for extrauterine existence.

Author Affiliations
Chapel Hill, NC

From the Medical Research Branch, Air Pollution Control Office, Environmental Protection Agency; and the Division of Newborn Services, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

Footnotes
Received for publication Oct 21, 1970; accepted Dec 1.

Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 4, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.

Reprint requests to 111 Research Bldg A, University of North Carolina, Chapel Hill, NC 27514 (Dr. Knelson).

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