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Lipid Composition of Pulmonary Tissue, Exfoliated Lining Cells, and Surfactant

Raymond C. Pfleger, PhD; Heather G. Thomas, PhD

Arch Intern Med. 1971;127(5):863-872.

Abstract
The lipids from normal beagle dog lungs, pulmonary surfactant, and exfoliated lining cells were quantitated by established procedures. The surfactant and cells were obtained by endobronchial saline lavage. Phospholipids accounted for more than 70% of the surfactant and cell lipids: phosphatidyl choline was the predominant phosphatide. Phosphatidyl glycerol is present in beagle dog pulmonary surfactant (10% of phospholipid-P), exfoliated lining cells (7% of phospholipid-P) and lung tissue (3% of phospholipid-P). Cholesterol and its esters accounted for more than 60% of the neutral lipid fractions. Alkyl and alk-1-enyl glycerol ethers were quantitated in the neutral lipids and phospholipids from all samples.

Author Affiliations
Albuquerque, NM

From the Lovelace Foundation for Medical Education and Research, Fission Product Inhalation Laboratories, Albuquerque, NM. Dr. Thomas is now with St. Luke's Hospital, Phoenix, Ariz.

Footnotes
Received for publication June 5, 1970; accepted Jan 26, 1971.

Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 4, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.

Reprint requests to 5200 Gibson Blvd, SE, Albuquerque, NM 87108 (Dr. Pfleger).

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