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A Statistical Analysis of Three Double-Blind Studies

Lothar Wertheimer, MD; Frank A. Finnerty, Jr., MD; Bernard A. Bercu, MD; Robert H. Hall, PhD

Arch Intern Med. 1971;127(5):934-938.

Abstract
The antihypertensive action of furosemide was evaluated in double-blind studies conducted in three different hospital clinics, by investigators following an identical protocol. The pressure lowering effect of furosemide was compared with that of a placebo in a randomized cross-over study. Both systolic and diastolic pressures were lowered significantly from pretreatment levels in over 50% of patients. No clinically important side effects attributable to furosemide were encountered in this study. Hyperuricemia was encountered in 31 of 44 patients. No significant disturbances of electrolyte balance were noted. Statistical analysis of the pooled data supported the conclusion that furosemide exerts an antihypertensive effect similar to that of other widely used sulfonamide diuretics, and therefore appears to be an effective agent for the treatment of mild to moderate hypertension.

Author Affiliations
New York; Washington, DC; Eloise, Mich; Cincinnati

From the Department of Medicine, New York Medical College Center for Chronic Disease, Bird S. Coler Hospital, Welfare Island, NY (Dr. Wertheimer); Department of Medicine, Georgetown University Medical Division, D. C. General Hospital, Washington, DC (Dr. Finnerty); Department of Medicine University of Michigan Medical School, Wayne County General Hospital, Eloise, Mich (Dr. Bercu); and Hoechst Pharmaceutical Company, Cincinnati (Dr. Hall).

Footnotes
Received for publication May 26, 1970; accepted Oct 15.

Reprint requests to Bird S. Coler Hospital, Welfare Island, New York 10017 (Dr. Wertheimer).

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