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Pulmonary Alveolar MacrophageMembrane Associated Sodium Ion, Potassium Ion, and Magnesium Ion Adenosine Triphosphatase System
Carroll E. Cross, MD;
Mohammad G. Mustafa, PhD;
Patricia Peterson;
Jeanne A. Hardie
Arch Intern Med. 1971;127(6):1069-1077.
Abstract
Pulmonary alveolar macrophages manifest a sodium ion-potassium ion activated, magnesium ion dependent adenosine triphosphatase (ATPase) activity. The characteristics of this ATPase were investigated in subcellular fractions and in intact cells derived from rabbits and sheep. Equimolar amounts of Mg+ + and ATP were needed for maximal activation by Na+ and K+. While Na+ or K+ alone had a little effect on ATPase, simultaneous addition of both cations, produced a 50% stimulation of basal activity. The Na+ -K+, Mg++ ATPase
Author Affiliations
Davis, Calif
From the departments of internal medicine and biological chemistry, School of Medicine, University of California, Davis.
Footnotes
Received for publication Oct 21, 1970; accepted March 3, 1971.
Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 3, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.
Reprint requests to Department of Internal Medicine, School of Medicine, University of California, Davis, Calif 95616 (Dr. Cross).
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