This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Donald E. Gardner, MS; Emil A. Pfitzer, ScD; Robert T. Christian, PhD; David L. Coffin, VMD

Arch Intern Med. 1971;127(6):1078-1084.

Abstract
A number of noxious agents have been shown to affect the function and numbers of pulmonary alveolar macrophages. A protective factor which inhibits the lysis of alveolar macrophages was found in fluid lavaged from normal rabbit lungs. The protective action is lost following the in vitro and in vivo action of ozone. Dipalmitoyl lecithin exhibits a similar protective action, which is also lost following the in vitro action of ozone. The surface tension properties of the protective factor and dipalmitoyl lecithin may be altered, but not destroyed, following exposure to ozone. It is hypothesized that many environmental stresses, including ozone, may act by primary inhibition of a protective factor in lung fluid, which results secondarily in lysis of alveolar macrophages with loss of this defense mechanism of the lung against inhaled microorganisms and particulate matter.

Author Affiliations
Cincinnati

From the Environmental Protection Agency, Air Pollution Control Office, Division of Effects Research, Cincinnati, and the Department of Environmental Health, College of Medicine, University of Cincinnati.

Footnotes
Received for publication Jan 29, 1971; accepted March 11.

Read before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 2, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.

Reprint requests to 1055 Laidlaw Ave, Cincinnati 45237 (Mr. Gardner).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Alterations in the Lung Following the Administration of Ozone
Huber et al.
Arch Intern Med 1971;128:81-87.
ABSTRACT  

Pulmonary Alveolar Macrophage: Membrane Associated Sodium Ion, Potassium Ion, and Magnesium Ion Adenosine Triphosphatase System
Cross et al.
Arch Intern Med 1971;127:1069-1077.
ABSTRACT