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Pulmonary Cell Responses to Metallic Oxides
Louis J. Casarett, PhD;
Margaret G. Casarett, MS;
Stephanie A. Whalen
Arch Intern Med. 1971;127(6):1090-1098.
Abstract
When the phagocytic response of pulmonary cells obtained from rat lung lavage to insoluble particles was assessed in an in vitro system under conditions of selected variables, a peak phagocytic response occurred for most metal oxides (except Fe2O3) at 10-4 M Ca++ and at 10-7 M UO2++ in a simple saline medium. The Ca++ effect was interrelated with particle concentration for SiO2 particles. Phagocytic response increased with particle to cell ratios up to 10 to 15 with several particle species. These and other data including enhanced phagocytosis with poly-L-lysine, are discussed in relation to peritoneal cell responses, charge characteristics of particles, and the implications of the findings to in vivo lung responses.
Author Affiliations
Honolulu
From the Department of Pharmacology, University of Hawaii School of Medicine, Honolulu.
Footnotes
Received for publication Oct 20, 1970; accepted March 11, 1971.
Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 5, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.
Reprint requests to Department of Pharmacology, University of Hawaii School of Medicine, 3675 Kilauea Ave, Honolulu 96816 (Dr. Casarett).
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