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Short-Term Exposure to Nitrogen DioxideEffects on Pulmonary Ultrastructure, Compliance, and the Surfactant System
Anthony R. Dowell, MD;
Kaye H. Kilburn, MD;
Philip C. Pratt, MD
Arch Intern Med. 1971;128(1):74-80.
Abstract
Eleven beagles were exposed to nitrogen dioxide in concentrations ranging from 3 to 16 ppm for one hour. Two control dogs were air-ventilated for one hour. Widespread bleb formation, loss of pinocytotic vesicles, and mitochondrial swelling of endothelial cells ensued. Intraalveolar edema occurred in most dogs exposed to 7 ppm NO2 or higher and membrane damage without edema occurred in the others. Intraalveolar edema by light microscopy was associated with impaired surfactant activity and lung compliance. Exposure to NO2 of 5 ppm or greater resulted in decrease of recovered lung lavage saturated lecithin. Exposure to 3 ppm NO2 resulted in bleb formation in alveolar endothelium without biochemical or physiological changes.
Author Affiliations
Durham, NC
From the departments of medicine and pathology, Duke University Medical Center, Durham, NC.
Footnotes
Received for publication Oct 21, 1970; accepted March 11,1971.
Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung Biochemistry, Richland, Wash, June 5, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.
Reprint requests to Muncie Clinic, 420 Washington St, Muncie, Ind 47302.
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