 |
|
Antioxidants vs Lung Disease
Jeffery N. Roehm, PhD;
John G. Hadley;
Daniel B. Menzel, PhD
Arch Intern Med. 1971;128(1):88-93.
Abstract
Oxidation of fatty acid methyl esters was markedly increased by trace quantities (1.5 ppm) of nitrogen dioxide or ozone. Nitrogen dioxide-catalyzed oxidation occurred through conventional peroxidation mechanisms. Ozone reacted in thin films by directly attacking the double bond. Phenolic antioxidants retarded NO2—but not O3—oxidation. In aqueous media, O3-oxidation occurred by direct attack and peroxidation; NO2-oxidation by conventional peroxidation. Both were retarded by phenolic antioxidants. Exposure of rats to 10 ppm NO2 for four weeks resulted in reduction of polyunsaturated fatty acids in the vitamin E-depleted group. Exposure to 1.0 ppm ozone resulted in death from pulmonary edema of all animals within 22 days. Lethal time for 50% of the population (LT50) was 8.2 days for vitamin E-depleted animals, and 18.5 days for those receiving vitamin E. Vitamin E appears to protect against the biological effects of photochemical air pollutants.
Author Affiliations
Richland, Wash
From the Biology Department, Pacific Northwest Laboratories, Battelle Memorial Institute, Richland, Wash. Dr. Menzel is now with Ross Laboratories, Columbus, Ohio.
Footnotes
Received for publication Oct 21, 1970; accepted March 3, 1971.
Read in part before the Tenth Annual Hanford Biology Symposium on Pollution and Lung
Biochemistry, Richland, Wash, June 5, 1970, jointly sponsored by the Battelle Memorial Institute-Pacific Northwest Laboratories, National Air Pollution Control Administration, National Institute of Environmental Health Sciences, and the US Atomic Energy Commission.
Reprint requests to Ross Laboratories, Columbus, Ohio 43216 (Dr. Menzel).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
The First Death From Nitrogen Dioxide Fumes: The Story of a Man and His Dog
Ramirez-R
JAMA 1974;229:1181-1182.
ABSTRACT
Linoleic Acid Hydroperoxide: Impaired Bacterial Uptake by Alveolar Macrophages, a Mechanism of Oxidant Lung Injury
Khandwala and Gee
Science 1973;182:1364-1365.
ABSTRACT
|
