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Paul F. Speckart, MD; John T. Nicoloff, MD; John E. Bethune, MD

Arch Intern Med. 1971;128(5):761-763.

Abstract
A screening procedure for adrenocortical insufficiency, utilizing (synthetic a 1-24 adrenocorticotropic hormone [ACTH] and a cortisol-binding globulin technique for serum cortisol, has been evaluated in normal subjects and in patients with primary and secondary adrenal insufficiency. Cosyntropin is injected by vein, and a serum cortisol concentration 60 minutes later is compared with a sample removed just prior to the cosyntropin administration. A clear separation of normal subjects from those with adrenal insufficiency is achieved.

Author Affiliations
Los Angeles

From the Department of Medicine, University of Southern California School of Medicine and the Los Angeles County-University of Southern California Medical Center, Los Angeles.

Footnotes
Received for publication July 31, 1970; accepted Dec 22, 1970.

Reprint requests to University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles 90033 (Dr. Bethune).

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