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Ionic Permeability Changes in Active Axon Membranes
Bertil Hille, PhD
Arch Intern Med. 1972;129(2):293-298.
Abstract
The propagation of impulses is explained by ionic permeability mechanisms in the axon membrane. Two different types of ionic channels, sodium channels and potassium channels, open and close in the membrane in response to changes of the membrane potential. Open channels allow ions to pass in or out of the axon at high rates as though the channel is a pore. Many neuropoisons and neuropharmacological drugs act directly to block, open, or in other ways change the properties of the ionic channels. The nature of the ionic channels in the axon seems to be the same in invertebrates and vertebrates.
Author Affiliations
Seattle
From the Department of Physiology and Biophysics, University of Washington, Seattle.
Footnotes
Received for publication July 28, 1971; accepted Sept 3.
Reprint requests to Department of Physiology and Biophysics, G412 Health Sciences Bldg, SH-40, University of Washington, Seattle 98105 (Dr. Hille).
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