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Freeze-Etching and Stereoscan Electron Microscopic Studies

Lawrence S. Lessin, MD; Wallace N. Jensen, MD; Panpit Klug, MD

Arch Intern Med. 1972;129(2):306-319.

Abstract
The ultrastructure of the red blood cell membrane and its surfaces is characterized by freeze-etching and stereoscan electron microscopy for the normal red blood cell and cells from patients with sickle cell anemia, hemoglobinopathy CC, and Heinz body hemolytic anemia. The external surface, intramembrane surfaces, and the internal surface of the normal red blood cell are described and the alterations of membranocytoplasmic relationships in the hemoglobinopathies studied are shown.

Author Affiliations
Washington, DC

From the Division of Hematology, Department of Medicine, George Washington University Medical Center, Washington, DC.

Footnotes
Received for publication Aug 26, 1971; accepted Nov 1.

Reprint requests to George Washington University Medical Center, 2150 Pennsylvania Ave NW, Washington, DC 20037 (Dr. Lessin).

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