 |
|
Hemodynamic and Metabolic Changes During Myocardial Ischemia
John O. Parker, MD, FACC
Arch Intern Med. 1972;129(5):790-798.
Abstract
Alterations in ventricular performance during myocardial ischemia were assessed by relating changes in left ventricular enddiastolic pressures to simultaneous changes in stroke work. Myocardial ischemia, whether induced by exercise or by atrial pacing, was associated with depressed left ventricular function. When angina was prevented by the prior administration of nitroglycerin, ventricular function was normal. Data are presented to indicate the importance of left ventricular volume on the development of angina and to support the concept that a major action of nitroglycerin may be in reducing myocardial oxygen requirements by reducing left ventricular volume. Metabolic studies during pacing-induced angina show a close temporal relationship between the onset of angina, ventricular dysfunction, anaerobic metabolism, and electrocardiographic abnormalities. The prevention of angina by nitroglycerin therapy does not regularly improve the metabolic abnormalities.
Author Affiliations
Kingston, Ontario, Canada
From the Cardiopulmonary Laboratory, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Footnotes
Received for publication Nov 1, 1971; accepted Feb 8, 1972.
Reprint requests to Cardiopulmonary Laboratory, Department of Medicine, Queen's University, Kingston, Ontario, Canada (Dr. Parker).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Effects of Smoking Marihuana on Left Ventricular Performance and Plasma Norepinephrine: Studies in Normal Men
GASH et al.
ANN INTERN MED 1978;89:448-452.
ABSTRACT
Diastolic Properties of the Left Ventricle
GROSSMAN and McLAURIN
ANN INTERN MED 1976;84:316-326.
ABSTRACT
Extrinsically Induced Arrhythmia in Acute Myocardial Infarction
Gross and Malaya
JAMA 1974;228:1021-1024.
ABSTRACT
|
