This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (20)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical and Chemical Abnormalities

Warren E. C. Wacker, MD; James F. Riordan, PhD; Phillip J. Snodgrass, MD; Lennig W. Chang, MD; Leonard J. Morse, MD; Thomas F. O'Brien, MD; William J. Reddy, DSc

Arch Intern Med. 1972;130(3):357-360.

Abstract
Ninety-seven men were exposed on the same day to infectious hepatitis in drinking water. One third developed icteric disease, 60% had anicteric disease, and 7% had no evidence of disease. Elevated serum glutamic pyruvic transaminase (SGPT) level was the most frequent chemical abnormality in the anicteric group. Serial measurements of the levels of SGPT, serum glutamic oxaloacetic transaminase (SGOT), ornithine carbamyl transferase (OCT), serum alkaline phosphatase, bilirubin, and cholesterol in the icteric group demonstrate the time course and extent of these abnormalities in this homogeneous population. The levels of serum bilirubin, alkaline phosphatase, and OCT decreased in parallel and were normal by 70 days after exposure. The SGPT and SGOT levels remained elevated longer. At 145 days after exposure, some patients still had elevated SGPT and SGOT levels. Transient hypercholesterolemia occurred in a significant number of patients reaching a maximum 55 days after exposure. The mean value was normal 25

Author Affiliations
Boston

From Georgetown University School of Medicine, Washington, DC; the departments of biological chemistry and medicine, Harvard Medical School, Boston; the College of the Holy Cross, Worcester, Mass; Peter Bent Brigham Hospital, Boston; and St. Vincent's Hospital, Worcester.

Footnotes
Received for publication July 7,1971; accepted Nov 1.

Reprint requests to Peter Bent Brigham Hospital, Boston 02115 (Dr. Wacker).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Revisiting the Holy Cross Football Team Hepatitis Outbreak (1969) by Serological Analysis
Friedman et al.
JAMA 1985;254:774-776.
ABSTRACT  

Viruses in Water
SMITH
ANN INTERN MED 1979;91:119-120.
ABSTRACT  

Infectious hepatitis in a college football player
Bowman
Am J Sports Med 1976;4:101-106.
ABSTRACT  

Parenterally Transmitted Hepatitis A Associated with Platelet Transfusions: Epidemiologic Study of an Outbreak in a Marrow Transplantation Center
MEYERS et al.
ANN INTERN MED 1974;81:145-151.
ABSTRACT