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Biochemical Steps and Mechanisms of Rate Control

Erwin H. Mosbach, PhD

Arch Intern Med. 1972;130(4):478-487.

Abstract
Bile acid synthesis in the liver is controlled by a negative feedback mechanism: hepatic bile acid synthesis varies inversely with the hepatic bile acid flux. Two regulatory enzymes appear to be involved in this process, cholesterol 7-hydroxylase and hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. It seems likely that the activity of these enzymes varies in response to changes in the magnitude, circulation rate, and composition of the bile acid pool.

Author Affiliations
New York

From the Department of Lipid Research, the Public Health Research Institute of the City of New York, Inc, and the Bureau of Laboratories, New York City Department of Health.

Footnotes
Received for publication April 3, 1972; accepted May 17.

Reprint requests to 455 First Ave, New York 10016.

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