Bile Acids, Liver Injury, and Liver Disease

doi:10.1001/archinte.1972.03650040130012

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Vol. 130 No. 4, October 1972

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Bile Acids, Liver Injury, and Liver Disease

Robert H. Palmer, MD

Arch Intern Med. 1972;130(4):606-617.

Abstract

Bile salts have deleterious effects on a variety of organs,cells, and subcellular organelles. Several bile salts, predominantlymonohydroxy bile salts, have the capacity to produce cholestasisand changes in gross liver structure and hepatocytic ultrastructurein experimental animals and in vitro preparations. It is alsoapparent that liver disease results in profound changes in thepattern of bile acid metabolism, some of which theoreticallycould be harmful and some protective. It is not possible atpresent to give a clear answer to the question of whether bilesalts participate in the initiation or perpetuation of humanliver disease, although the evidence reviewed here suggeststhat in certain circumstances they may.

Author Affiliations

Chicago

From the Department of Medicine, University of Chicago Pritzker School of Medicine, and Argonne Cancer Research Hospital, Chicago.

Footnotes

Received for publication April 3, 1972; accepted May 17, 1972.

Reprint requests to 950 E 59th St, Chicago 60637.

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