This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (129)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Blood Pressure Response and Plasma Renin Activity

E. Victor Adlin, MD; Allan D. Marks, MD; Bertram J. Channick, MD

Arch Intern Med. 1972;130(6):855-858.

Abstract
Hypertensive patients with low plasma renin activity are suspected of having mineralocorticoid excess. We treated 26 hypertensive patients with the mineralocorticoid antagonist, spironolactone, 200 mg daily, and 25 patients with hydrochlorothiazide, 100 mg daily, for 12 weeks. Patients with low renin activity (below 250 ng/100 ml, 10 mEq sodium diet, upright position) and low normal renin activity (250 to 400 ng/100 ml) responded to both drugs with a significantly larger fall in blood pressure than was achieved by patients with renin activity above 400 ng/100 ml. Fall in blood pressure was related to the initial weight loss induced by spironolactone (r =.51), but was not related to the weight loss induced by hydrochlorothiazide. Both spironolactone and hydrochlorothiazide are more effective in reducing blood pressure in patients with low and low-normal renin activity than in other hypertensive patients.

Author Affiliations
Philadelphia

From the Section of Endocrinology, Department of Medicine, Temple University School of Medicine, Philadelphia.

Footnotes
Submitted for publication Aug 1, 1972; accepted Oct 11.

Reprint requests to 3401 N Broad St, Philadelphia 19140 (Dr. Adlin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Influence of Renin Levels on the Treatment of Essential Hypertension With Thiazide Diuretics
Wyndham et al.
Arch Intern Med 1987;147:1021-1025.
ABSTRACT  

Dietary Sodium and Essential Hypertension: Some Myths, Hopes, and Truths
LARAGH and PECKER
ANN INTERN MED 1983;98:735-743.
ABSTRACT  

Racial Difference in Salivary Sodium-Potassium Ratio in Low Renin Essential Hypertension
Adlin et al.
Arch Intern Med 1982;142:703-706.
ABSTRACT  

Role of Renin Classification for Diuretic Treatment of Black Hypertensive Patients
Holland et al.
Arch Intern Med 1979;139:1365-1370.
ABSTRACT  

Short-term Therapy of Severe Hypertension: Hemodynamic Correlates of the Antihypertensive Response in Man
Sullivan et al.
Arch Intern Med 1979;139:1233-1239.
ABSTRACT  

Antihypertensive Comparison of Furosemide With Hydrochlorothiazide for Black Patients
Holland et al.
Arch Intern Med 1979;139:1015-1021.
ABSTRACT  

A Composite Analysis of Renin Classification Methods
Holle et al.
Arch Intern Med 1978;138:1514-1519.
ABSTRACT  

The Determinants of Plasma-Renin Activity in Essential Hypertension
ESLER et al.
ANN INTERN MED 1978;88:746-752.
ABSTRACT  

Diuretic Therapy and Response of Essential Hypertension to Saralasin
ANDERSON et al.
ANN INTERN MED 1977;87:183-187.
ABSTRACT  

Renin Reactivity as a Determinant of Responsiveness to Antihypertensive Treatment
Weber et al.
Arch Intern Med 1977;137:284-289.
ABSTRACT  

The Intravenous Furosemide Test: A Simple Way to Evaluate Renin Responsiveness
KAPLAN et al.
ANN INTERN MED 1976;84:639-645.
ABSTRACT  

Triamterene-Induced Changes in Aldosterone and Renin Values in Essential Hypertension: Evidence of a Role for Aldosterone in Preventing Blood Pressure Reduction
Keim et al.
Arch Intern Med 1976;136:645-648.
ABSTRACT  

Antihypertensive Drugs in Combination: Effects of Methyldopa on Thiazide-Induced Changes in Renal Hemodynamics and Plasma Renin Activity
Kaplan
Arch Intern Med 1975;135:660-663.
ABSTRACT  

Low-Renin Hypertension: Occurrence in Vascular Complications
Gulati et al.
Arch Intern Med 1975;135:260-263.
ABSTRACT  

The Prognostic Implications of Plasma Renin in Essential Hypertension
Kaplan
JAMA 1975;231:167-170.
ABSTRACT  

Treatment of Low-Renin Essential Hypertension: Comparison of Spironolactone and a Hydrochlorothiazide-Triamterene Combination
Douglas et al.
JAMA 1974;227:518-521.
ABSTRACT  

Low-Renin Hypertension: Restoration of Normotension and Renin Responsiveness
Spark et al.
Arch Intern Med 1974;133:205-211.
ABSTRACT