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Alveolar Clearance of Aerosols
Paul E. Morrow, PhD
Arch Intern Med. 1973;131(1):101-108.
Abstract
The alveolar region of the lungs is endowed with several "cleansing" mechanisms whereby nongaseous substances of intrinsic and extrinsic origins are continuously removed. Collectively, the clearance mechanisms and pathways can be categorized into those effecting the removal of the readily transportable materials, eg, dissolved or monomeric substances, by passive and active absorption processes; and of the more persistent, less easily transportable materials, eg, "insoluble" dusts, by endocytosis and dissolution. The author critically assesses various clearance concepts and reviews the salient physiological and anatomical considerations that underly these concepts.
Author Affiliations
Rochester, NY
From the departments of radiation biology and biophysics, and pharmacology and toxicology, University of Rochester (NY) Medical Center.
Footnotes
Received for publication May 25, 1972; accepted June 1, 1972.
Reprint requests to Dept of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, Crittenden Ave, Rochester, NY 14642 (Dr. Morrow).
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