Howell-Jolly Bodies: Intracellular or Extracellular?

doi:10.1001/archinte.1973.00320080072009

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Vol. 131 No. 2, February 1973

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Howell-Jolly Bodies

Intracellular or Extracellular?

Robert W. Hilberg, MD; Robert D. Ringle; Stanley P. Balcerzak, MD

Arch Intern Med. 1973;131(2):236-237.

Abstract

Howell-Jolly (H-J) bodies have classically been considered intracellularremnants of the normoblast nucleus that once occupied the redblood cell in which the inclusion is seen. Recent work, supportedby light microscopic findings, has suggested these inclusionsmay be extracellular. Extensive scanning and electron microscopicstudy of H-J red blood cells has confirmed their intracellularlocation.

Author Affiliations

Columbus, Ohio

From the Division of Hematology, Department of Medicine, Ohio State University College of Medicine, Columbus.

Footnotes

Received for publication Jan 3, 1972; accepted March 21.

Reprint requests to Ohio State University College of Medicine,410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Balcerzak).

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