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in Hodgkin's Disease

John E. Ultmann, MD, FACP; Edgar M. Moran, MD

Arch Intern Med. 1973;131(3):332-353.

Abstract
A review of the clinical course and complications of Hodgkin's disease stresses the recently acquired knowledge on its modes of spread with particular emphasis on lymphatic and vascular dissemination. The available data supporting these pathways of progression are correlated with the clinical events in the course of this disease. The manifestations related to the tumor involvement of different organs as well as those representing the remote effects of this malignant process on different systems are considered. The nonspecific clinical manifestations, as well as hematologic, metabolic, and endocrine-like complications are surveyed. Finally, the interrelationship of Hodgkin's disease with various conditions characterized by immunologic aberrations is discussed.

Author Affiliations
Chicago

From the Department of Medicine, Pritzker School of Medicine, Division of Biological Sciences, University of Chicago, and the Argonne Cancer Research Hospital (operated by the University of Chicago for the United States Atomic Energy Commission), Chicago.

Footnotes
Received for publication Sept 13, 1972; accepted Oct 2.

Read before the Symposium on Hodgkin's Disease, St. Louis, Oct 9, 1971, sponsored by the National Cancer Institute, Cancer Clinical Investigation Review Committee, Clinical Investigations Branch.

Reprint requests to Department of Medicine, University of Chicago, 950 E 59th St, Chicago 60637 (Dr. Ultmann).

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