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Antibodies to Native DNA in Systemic Lupus ErythematosusA Technique of Rapid and Quantitative Determination
Nicholas M. Kredich, MD;
Jay S. Skyler, MD;
Linda J. Foote
Arch Intern Med. 1973;131(5):639-644.
Abstract
The nitrocellulose membrane technique for detecting DNA-protein complexes was used to demonstrate antibodies to native DNA in the sera of patients with systemic lupus erythematosus (SLE). Such antibodies were found in 19 of 21 patients with active SLE, in ten of 12 patients with inactive SLE, and in three of 217 controls. This rapidly performed assay is easily quantified and can be useful in the diagnosis and management of patients with SLE.
Author Affiliations
Durham, NC
From the Division of Rheumatic and Genetic Diseases, Department of Medicine, and the Department of Biochemistry, Duke University Medical Center, Durham, NC.
Footnotes
Received for publication July 20, 1972; accepted Nov 22.
Reprint requests to Box 3100, Duke University Medical Center, Durham, NC 27710 (Dr. Kredich).
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