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Oxymetholone in Myelofibrosis and Chronic Lymphocytic Leukemia
Cary A. Presant, MD;
Shabbir H. Safdar, MD
Arch Intern Med. 1973;132(2):175-178.
Abstract
Five patients with myelofibrosis and three with chronic lymphocytic leukemia (CLL) who had erythroblastopenic anemia refractory to antineoplastic therapy were treated with oxymetholone, 1.6 to 2.4 mg/kg of body weight per day. Four of the five patients with myelofibrosis and all three with CLL had a decrease in transfusion requirements and a mean maximum increase in hemoglobin concentration of 105%. Platelet counts increased in four of eight cases, and leukocyte counts increased in three of four leukopenic patients. Discontinuation of oxymetholone therapy or a decrease in dose below 1.0 mg/kg/day nearly always resulted in a relapse of the anemia. Mild hepatotoxicity was observed in four, virilization in two, hyperuricemia in one, and edema in all patients. Oxymetholone is at least as effective as other anabolic steroids in erythroblastopenic myelofibrosis and CLL and may be the treatment of choice.
Author Affiliations
St. Louis
From the Division of Hematology, Department of Medicine, Washington University School of Medicine; the Research Hematology Laboratory, the John Cochran Veterans Administration Hospital; and the Jewish Hospital of St. Louis, St. Louis.
Footnotes
Received for publication July 29, 1971; accepted Aug 26, 1972.
Reprint requests to Department of Medicine, Jewish Hospital of St. Louis, 216 S Kingshighway, St. Louis, MO 63110 (Dr. Presant).
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